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KMID : 0191120200350190151
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Journal of Korean Medical Science
2020 Volume.35 No. 19 p.151 ~ p.151
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Predicting First-Year Growth in Response to Growth Hormone Treatment in Prepubertal Korean Children with Idiopathic Growth Hormone Deficiency: Analysis of Data from the LG Growth Study Database
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Cho Won-Kyoung
Ahn Moon-Bae
Kim Eun-Young
Cho Kyoung-Soon
Jung Min-Ho
Suh Byung-Kyu
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Abstract
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Background: The first-year growth in response to growth hormone (GH) treatment seems to be the most important factor in determining the overall success of GH treatment.
Methods: Data from children (n = 345) who were in the LG Growth Study Database were used to develop a model. All subjects had been diagnosed with idiopathic growth hormone deficiency (GHD) and presented in a prepubertal state during the first year of GH treatment.
Results: The Δheight standard deviation score (SDS) during 1st year of GH treatment was correlated positively with weight-SDS (β = 0.304, P < 0.001), body mass index (BMI)-SDS (β = 0.443, P < 0.001), paternal height-SDS (β = 0.296, P = 0.001), MPH-SDS (β = 0.421, P < 0.001) and MPH SDS minus baseline height SDS (β = 0.099, P < 0.001) but negatively with chronological age (β = ?0.294, P < 0.001), bone age (β = ?0.249, P < 0.001). A prediction model of 1st year growth in response to GH treatment in prepubertal Korean children with idiopathic GHD is as follows: Δheight SDS during 1st year of GH treatment = 1.06 ? 0.05 × age + 0.09 × (MPH SDS minus baseline height SDS) + 0.05 × BMI SDS. This model explained 19.6% of the variability in the response, with a standard error of 0.31.
Conclusion: The present model to predict first-year response to GH treatment might allow more tailored and personalized GH treatment in Korean prepubertal children with idiopathic GHD.
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KEYWORD
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Prediction, Growth Hormone Deficiency, Treatment
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